Which of the following does not give nucleophilic substitution with alcohol?
$CH_{3}COCl$
Acetic anhydride
Ether
None of the above
Explanation:
Hint: Ether mixed with alcohol then no reaction occurs
Acetyl chloride and acetic anhydride react with alcohol and form an ester as a product. The reaction is an example of a nucleophilic acyl substitution reaction. In a nucleophilic substitution reaction, strong nucleophiles substitute weak nucleophiles.
The reaction is as follows:
But when Alcohol reacts with ether then no reaction occurs because ether and alcohol both act as a nucleophile and two nucleophiles do not react with each other. Hence, ether is the correct answer.
